Many forms of arthritis and related conditions that affect the joints, muscles, and/or bones can cause problems like pain, stiffness, and swelling in the wrist and fingers. Other conditions can cause additional problems, such as numbness and tingling, pitted nails, painful ulcers, or thickened skin that makes bending the fingers difficult. Spine Center of Texas has prepared a list of the most common disease-related problems that affect the hands and wrists.